IL-4 Recombinant Protein Cat. No.: 40-464

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psi-iconSpecifications
SPECIES:Rat
SOURCE SPECIES:E. coli
SEQUENCE:MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS
BIOLOGICAL ACTIVITY: Determined by its ability to stimulate rat NB2-11 cell survival in low serum conditions using a concentration range of 3.0-7.0 ng/ml.
psi-iconProperties
PURITY:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized IL-4 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:Il4e12, Il-4, Interleukin-4, B-cell IGG differentiation factor, IL-4
ACCESSION NO.:NP_958427.1
PROTEIN GI NO.:42627877
OFFICIAL SYMBOL:Il4
GENE ID:287287
psi-iconBackground and References
BACKGROUND:IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant rat IL-4 is a 14.0 kDa globular protein containing 126 amino acid residues.

FOR RESEARCH USE ONLY.

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