IL-4 R alpha Recombinant Protein Cat. No.: 96-797

Availability: In stock

$0.00

 Price Options

$0.00
psi-iconSpecifications
SPECIES:Cynomolgus, Rhesus macaque
SOURCE SPECIES:HEK293 cells
SEQUENCE:Met 26 - Arg 232
FUSION TAG:Fc Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:50.4 kDa
PHYSICAL STATE:Lyophilized
BUFFER:Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:IL4R,CD124,IL4RA
ACCESSION NO.:G7Q0S7
OFFICIAL SYMBOL:IL-4 R alpha
psi-iconBackground and References
BACKGROUND:IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Ralpha (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin 4 Receptor (IL4R) also known as CD124, IL4Ralpha and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.
REFERENCES:1) Ikizawa, K., et al., 2000, Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54–9.
2) Kashiwada, M., et al., 2001, J. Immunol. (United States) 167 (11): 6382–7.
3) Hage T., et al., 1999, Cell 97 (2): 271–81.
4) Gessner,A. et al., 2000, Immunobiology. 201 (3-4): 285-307.

FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.