| SPECIES: | Mouse |
| SOURCE SPECIES: | CHO cells |
| SEQUENCE: | The extracellular domain of mouse IL-22 (aa 34-179) is fused to the N-terminus of the Fc region of mouse IgG2a. |
| FUSION TAG: | Fc Tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant proteins is for research use only. |
| BIOLOGICAL ACTIVITY: | N/A |
Specifications| PURITY: | >98% (SDS-PAGE). Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza). |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS. |
| STORAGE CONDITIONS: | Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C. |
| ALTERNATE NAMES: | Interleukin-22, IL-10-related T Cell-derived-inducible Factor |
| ACCESSION NO.: | NP_058667 |
| PROTEIN GI NO.: | 8393605 |
| OFFICIAL SYMBOL: | Il22 |
| GENE ID: | 50929 |
| BACKGROUND: | Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family. |
FOR RESEARCH USE ONLY.
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