IL-22 Recombinant Protein Cat. No.: 40-426

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psi-iconSpecifications
SPECIES:Murine
SOURCE SPECIES:E. coli
SEQUENCE:MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV
BIOLOGICAL ACTIVITY: Biological activity was determined by its ability to induce STAT3 activation in COLO 205 cells. The expected ED50 for this effect is 150-400 pg/ml.
psi-iconProperties
PURITY:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized IL-22 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-22 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-22 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:IL-22, Iltif, IL-22a, ILTIFa, Il22a, Iltifa, Interleukin-22, IL-10-related T-cell-derived-inducible factor, IL-22
ACCESSION NO.:NP_058667.1
PROTEIN GI NO.:8393605
OFFICIAL SYMBOL:Il22
GENE ID:50929
psi-iconBackground and References
BACKGROUND:IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 33.4 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

FOR RESEARCH USE ONLY.

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