IL-21 Antibody [SB134f] Cat. No.: 99-804

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
IMMUNOGEN: E. coli-expressed human IL-21
TESTED APPLICATIONS: Electron Microscopy, ELISA, Flow, ICC, IHC-Fr, IHC-P, IP, WB
APPLICATIONS: IL-21 Antibody [SB134f] for use in ELISA assays.
SPECIFICITY: IL-21

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2a
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
CONCENTRATION:0.5 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:IL21
ALTERNATE NAMES:Interleukin-21, Za11
ACCESSION NO.:Q9HBE4
GENE ID:59067
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

ANTIBODIES FOR RESEARCH USE ONLY.

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