| SPECIES: | Human |
| SOURCE SPECIES: | NS1 cells |
| SEQUENCE: | The extracellular domain of human IL-2 (aa 21-153) is fused to the N-terminus of the Fc region of a mutant human IgG1. |
| FUSION TAG: | Fc Tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant proteins is for research use only. |
| BIOLOGICAL ACTIVITY: | Shows the biological function of the IL-2 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. |
Specifications| PURITY: | >98% (SDS-PAGE). Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza). |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μl sterile water. Add 1X PBS to the desired protein concentration. |
| STORAGE CONDITIONS: | Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C. |
| ALTERNATE NAMES: | Interleukin-2, Aldesleukin |
| ACCESSION NO.: | NP_000577 |
| PROTEIN GI NO.: | 28178861 |
| OFFICIAL SYMBOL: | IL2 |
| GENE ID: | 3558 |
| BACKGROUND: | Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens. |
FOR RESEARCH USE ONLY.
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