IL-2 Antibody [1Q8G7] Cat. No.: 11-090

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Virus
IMMUNOGEN: Recombinant Human IL2 Protein, amino acids Ala21-Thr153
TESTED APPLICATIONS: ELISA
APPLICATIONS: Human IL-2 Sanwich ELISA Immunoassay:

ELISA Capture: Recommended Concentration: 2-8ug/mL, Sample: Human IL-2 Monoclonal Antibody, Rabbit MAb(CAP)

ELISA Detection: Recommended Concentration: 0.15-0.5ug/mL, Sample: Human IL-2 Monoclonal Antibody, Rabbit MAb (DET)

Standard: Recommended Concentration: 0.78-50pg/mL, Sample: Recombinant Human IL2 Protein


psi-iconProperties
PURIFICATION:Affinity Purified, Endotoxin Level: < 1.0 EU/ug of the protein by LAL method.
CLONALITY:Monoclonal
ISOTYPE:Rabbit IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied as a 0.2um filtered solution in PBS, pH 7.4.
CONCENTRATION:1mg/ml
STORAGE CONDITIONS:This antibody can be stored at 2˚C to -8˚C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20˚C to -80˚C. Preservative-Free. Avoid repeated freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:IL2
ALTERNATE NAMES:IL-2; TCGF; lymphokine
PROTEIN GI NO.:45593462
GENE ID:3558
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Interleukin-2 (IL-2) is a O-glycosylated, four alpha -helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis. IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells.

ANTIBODIES FOR RESEARCH USE ONLY.

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