| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| IMMUNOGEN: | IL-1RL2 antibody was raised against a 16 amino acid peptide near the center of human IL-1RL2. The immunogen is located within amino acids 260 - 310 of IL-1RL2. |
| TESTED APPLICATIONS: | ELISA, IF, IHC-P, WB |
| APPLICATIONS: | IL-1RL2 antibody can be used for detection of IL-1RL2 by Western blot at 1 - 2 μg/ml. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. |
| SPECIFICITY: | IL-1RL2 antibody is human, mouse and rat reactive. At least three isoforms of IL-1RL2 are known to exist; this antibody will detect all three isoforms. IL-1RL2 antibody is predicted to not cross-react with IL-1R or IL-1RL1. |
| POSITIVE CONTROL: | 1) Cat. No. 1308 - Human Small Intestine Tissue Lysate |
| 2) Cat. No. 11-801 - Human Small Intestine Tissue Slide | |
| PREDICTED MOLECULAR WEIGHT: | Predicted: 61 kDa Observed: 55 kDa |
Specifications| PURIFICATION: | IL-1RL2 antibody is affinity chromatography purified via peptide column. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | IL-1RL2 antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | IL-1RL2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| OFFICIAL SYMBOL: | IL1RL2 |
| ALTERNATE NAMES: | IL-1RL2 Antibody: IL-36R, IL1RRP2, IL-1Rrp2, IL1R-rp2, Interleukin-1 receptor-like 2, IL-36 receptor, IL-36R |
| ACCESSION NO.: | NP_003845 |
| PROTEIN GI NO.: | 28416902 |
| GENE ID: | 8808 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1). Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2). IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3). |
| REFERENCES: | 1) Lovenberg TW, Crowe PD, Liu C, et al. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1 1R-rp2). J. Neuroimmunol. 1996; 70:113-22. | 2) Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 2004; 279:13677-88. | 3) van de Veerdonk FL, Stoeckman AK, Wu G, et al. IL-38 beinds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc. Natl. Acad. Sci. USA 2012; 109:3001-5. |
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