Datasheet

IL-1F10 Antibody
CATALOG NUMBER: 7503

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Mouse: (100%)
TESTED APPLICATIONS:ELISA, IHC-P, WB
APPLICATIONS:IL-1F10 antibody can be used for detection of IL-1F10 by Western blot at 1 - 2 μg/ml
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1304 - Human Liver Tissue Lysate
 2) Cat. No. 10-901 - Human Spleen Tissue Slide
PREDICTED MOLECULAR WEIGHT:Predicted: 17 kDa

Observed: 20 kDa
SPECIFICITY:IL-1F10 antibody is human, mouse and rat reactive. Two isoforms of IL-1F10 exist.
IMMUNOGEN:IL-1F10 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IL-1F10.

The immunogen is located within the last 50 amino acids of IL-1F10.
HOST SPECIES:Rabbit

Properties

PURIFICATION:IL-1F10 antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:IL-1F10 antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:IL-1F10 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:IL-1F10 Antibody: IL-38, FKSG75, IL1HY2, IL-1HY2, IL1-theta, FIL1-theta, FIL1T, IL38, UNQ6119/PRO20041, Interleukin-1 family member 10, Family of interleukin 1-theta, IL-1F10
ACCESSION NO.:NP_775184
PROTEIN GI NO.:27894307
OFFICIAL SYMBOL:IL1F10
GENE ID:84639

Background

BACKGROUND:The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection (1). IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil (2). IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses (3). IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis (4).
REFERENCES: 1) Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 2004; 279:13677-88.
2) Lin H, Ho AS, Haley-Vicente D, et al. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. J. Biol. Chem. 2001; 276: 20597-602.
3) Bensen JT, Dawson PA, Mychaleckyj JC, et al. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J. Interferon Cytokine Res. 2001; 21:899-904.
4) Cruz-Robles D, Chavez-Gonzalez JP, Cavazos-Quero MM, et al. Association between IL-1B and IL-1RN gene polymorphisms and Chagas' disease development susceptibility. Immunol. Invest. 2009; 38:231-9.

For Research Use Only