Specifications
| HOST SPECIES: | Rat |
| SPECIES REACTIVITY: |
Mouse, Rat |
| TESTED APPLICATIONS: |
Flow |
| SPECIFICITY: |
The 17B7 monoclonal antibody specifically binds to mouse and rat IL-17A, a pro-inflammatory cytokine. |
Properties
| PURIFICATION: | The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
| CLONALITY: | Monoclonal |
| ISOTYPE: | Rat IgG2a, kappa |
| CONJUGATE: | FITC |
| PHYSICAL STATE: | liquid |
| BUFFER: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| CONCENTRATION: | batch dependent |
| STORAGE CONDITIONS: | The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze. |
Additional Info
| OFFICIAL SYMBOL: | Il17a |
| ALTERNATE NAMES: | Il17, Ctla8, IL-17, Ctla-8, IL-17A, Il17a |
| GENE ID: | 16171; 301289 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
Background and References
| BACKGROUND: | The 17B7 monoclonal antibody specifically binds to mouse and rat IL-17A, a pro-inflammatory cytokine. It is produced by T helper 17 (Th17) cells, a unique subset of IL-23 dependent CD4+ T cells. Interleukin-17A is highly expressed in transplant rejection, asthma, psoriasis, and multiple sclerosis, and enhances the expression of ICAM-1 in human fibroblasts. The homodimer is expressed by activated peripheral CD4+ T lymphocytes. The Interleukin-17A binds to the IL-17 receptors (IL-17R) expressed by mast cells, monocytes and macrophages, fibroblasts, and endothelial and epithelial cells. |
ANTIBODIES FOR RESEARCH USE ONLY.
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