IL-15RA Antibody Cat. No.: 7233

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: Rabbit polyclonal IL-15RA antibody was raised against a 16 amino acid peptide near the center of human IL-15RA.

The immunogen is located within amino acids 40 - 90 of IL-15RA.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: IL-15RA antibody can be used for detection of IL-15RA by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
SPECIFICITY: Multiple isoforms of IL-15RA are known to exist.
POSITIVE CONTROL:1) Cat. No. 1468 - Rat Small Intestine Tissue Lysate
PREDICTED MOLECULAR WEIGHT: Predicted: 26, 30, 38 kDa

Observed: 30 kDa

psi-iconProperties
PURIFICATION:IL-15RA Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:IL-15RA Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:IL-15RA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:IL15RA
ALTERNATE NAMES:IL-15RA Antibody: CD215, Interleukin-15 receptor subunit alpha, IL-15 receptor subunit alpha
ACCESSION NO.:NP_001243694
PROTEIN GI NO.:377520151
GENE ID:3601
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:IL-15RA Antibody: Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2.
REFERENCES:1) Giri JG, Kumaki S, Ahdieh M, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995; 14:3654-63.
2) Bodnar A, Nizsaloczki E, Mocsar G, et al. A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. Immunol. Lett. 2008; 116:117-25.
3) Lorenz HM, Hieronymus T, Grunke M, et al. Differential role for IL-2 and IL-15 in the inhibition of apoptosis in short-term activated human lymphocytes. Scand. J. Immunol. 1997; 45:660-9.

ANTIBODIES FOR RESEARCH USE ONLY.

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