IL-13 Recombinant Protein Cat. No.: 40-470

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psi-iconSpecifications
SPECIES:Rat
SOURCE SPECIES:E. coli
SEQUENCE:TPGPVRRSTS PPVALRELIE ELSNITQDQK TSLCNSSIVW SVDLTAGGFC AALESLTNIS SCNAIHRTQR ILNGLCNQKA SDVASSPPDT KIEVAQFISK LLNYSKQLFR YGH
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: The ED50 was determined by the dose - dependent proliferation of TF - 1 cells is < 5.0 ng/mL, corresponding to a specific activity of > 2 x 105 units/mg.
psi-iconProperties
PURITY:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized IL-13 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-13 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-13 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:Il-13, Interleukin-13, T-cell activation protein P600, IL-13
ACCESSION NO.:NP_446280.1
PROTEIN GI NO.:16758680
OFFICIAL SYMBOL:Il13
GENE ID:116553
psi-iconBackground and References
BACKGROUND:IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 12.3 kDa protein consisting of 113 amino acid residues.

FOR RESEARCH USE ONLY.

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