IL-10 Recombinant Protein Cat. No.: 40-471

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psi-iconSpecifications
SPECIES:Rat
SOURCE SPECIES:E. coli
SEQUENCE:SKGHSIKGDN NCTHFPVSQT HMLRELRAAF SQVKTFFQKK DQLDNIVLTD SLLQDFKGYL GCQALSEMIK FYLVEVMPQA ENHGPEIKEH LNSLGEKLKT LWIQLRRCHR FLPCENKSKA VEQVKNDFNK LQDKGVYKAM NEFDIFINCI EAYVTLKMKN
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: The ED50 was determined by the dose - dependent inhibition of antigen - specific T cell proliferation is less than 10 ng/mL.
psi-iconProperties
PURITY:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized IL-10 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-10 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-10 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:IL10X, Il-10, Interleukin-10, Cytokine synthesis inhibitory factor, IL-10
ACCESSION NO.:NP_036986.2
PROTEIN GI NO.:148747382
OFFICIAL SYMBOL:Il10
GENE ID:25325
psi-iconBackground and References
BACKGROUND:IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant rat IL-10 is an 18.7 kDa protein of 160 amino acid residues.

FOR RESEARCH USE ONLY.

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