| SPECIES: | Human |
| SOURCE SPECIES: | NS1 cells |
| SEQUENCE: | The extracellular domain of human IL-10 (aa 19-178) is fused to the N-terminus of the Fc region of a mutant human IgG1. |
| FUSION TAG: | Fc Tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant proteins is for research use only. |
| BIOLOGICAL ACTIVITY: | Bioactivity demonstrated in cytokine synthesis inhibition assay, measuring inhibition of IL-6 production by PU5-1 cells. |
Specifications| PURITY: | >98% (SDS-PAGE). Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza). |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μl sterile water. Add 1X PBS to the desired protein concentration. |
| STORAGE CONDITIONS: | Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C. |
| ALTERNATE NAMES: | Interleukin-10, Cytokine Sythesis Inhibitory Factor, CSIF |
| ACCESSION NO.: | NP_000563 |
| PROTEIN GI NO.: | 10835141 |
| OFFICIAL SYMBOL: | IL10 |
| GENE ID: | 3586 |
| BACKGROUND: | Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. |
FOR RESEARCH USE ONLY.
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