| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Pig, Rat |
| IMMUNOGEN: | Recombinant protein of human IKB alpha |
| TESTED APPLICATIONS: | Flow, IF, IHC, IP, WB |
| APPLICATIONS: | WB: ,1:500 - 1:1000 IHC: ,1:50 - 1:100 IF: ,1:20 - 1:50 IP: ,1:20 - 1:50 Flow: ,1:20 - 1:50 |
| POSITIVE CONTROL: | 1) Jurkat |
| PREDICTED MOLECULAR WEIGHT: | Observed: 36kDa |
Specifications| PURIFICATION: | Affinity purification |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| STORAGE CONDITIONS: | Store at -20˚C. Avoid freeze / thaw cycles. |
| OFFICIAL SYMBOL: | NFKBIA |
| ALTERNATE NAMES: | NFKBIA, IKBA, MAD-3, NFKBI |
| GENE ID: | 4792 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. |
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