IGF-I R / CD221 Recombinant Protein Cat. No.: 11-444

Availability: In stock

$0.00

 Price Options

$0.00
psi-iconSpecifications
SPECIES:Rat
SOURCE SPECIES:HEK293 cells
SEQUENCE:Glu 31 - His 936
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. This protein contains a furin convertase cleavage site, 738-RRRR-741, and will be partially processed into N (α chain) and C-terminal fragment (partial β chain) with calculated MW of 81.3 kDa and
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:81.3 kDa and 24.2 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:IGF1R,IGFR,JTK13,CD221,MGC142170,MGC142172,MGC18216
ACCESSION NO.:NP_434694.1
OFFICIAL SYMBOL:Igf1r
GENE ID:25718
psi-iconBackground and References
BACKGROUND:The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
REFERENCES:1) Jones JI, Clemmons DR., 1995, Endocr. Rev. 16 : 3–34.
2) LeRoith D, et al., 1995, Endocr. Rev. 16 (2): 143–63.

FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.