IFN gamma Recombinant Protein Cat. No.: 40-472

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psi-iconSpecifications
SPECIES:Rat
SOURCE SPECIES:E. coli
SEQUENCE:MQGTLIESLE SLKNYFNSSS MDAMEGKSLL LDIWRNWQKD GNTKILESQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT NFFSNSKAKK DAFMSIAKFE VNNPQIQHKA VNELIRVIHQ LSPESSLRKR KRSRC
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: The ED50 was determined by a cytopathic affect inhibition assay with murine L929 cells challenged with EMC virus was < 0.1 ng/mL, corresponding to a specific activity of > 1 x 107 units/mg.
psi-iconProperties
PURITY:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized IFN gamma recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IFN gamma is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IFN gamma recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:IFNG2, Interferon gamma, IFN-gamma
ACCESSION NO.:NP_620235.1
PROTEIN GI NO.:20302055
OFFICIAL SYMBOL:Ifng
GENE ID:25712
psi-iconBackground and References
BACKGROUND:IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma is species-specific and is biologically active only in human and primate cells. Recombinant rat IFN-gamma is a 15.6 kDa protein containing 135 amino acid residues.

FOR RESEARCH USE ONLY.

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