| SPECIES: | Rat |
| SOURCE SPECIES: | E. coli |
| SEQUENCE: | MQGTLIESLE SLKNYFNSSS MDAMEGKSLL LDIWRNWQKD GNTKILESQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT NFFSNSKAKK DAFMSIAKFE VNNPQIQHKA VNELIRVIHQ LSPESSLRKR KRSRC |
| TESTED APPLICATIONS: | |
| BIOLOGICAL ACTIVITY: | The ED50 was determined by a cytopathic affect inhibition assay with murine L929 cells challenged with EMC virus was < 0.1 ng/mL, corresponding to a specific activity of > 1 x 107 units/mg. |
Specifications| PURITY: | Greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
| PHYSICAL STATE: | Lyophilized |
| STORAGE CONDITIONS: | The lyophilized IFN gamma recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IFN gamma is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IFN gamma recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
| ALTERNATE NAMES: | IFNG2, Interferon gamma, IFN-gamma |
| ACCESSION NO.: | NP_620235.1 |
| PROTEIN GI NO.: | 20302055 |
| OFFICIAL SYMBOL: | Ifng |
| GENE ID: | 25712 |
| BACKGROUND: | IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma is species-specific and is biologically active only in human and primate cells. Recombinant rat IFN-gamma is a 15.6 kDa protein containing 135 amino acid residues. |
FOR RESEARCH USE ONLY.
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