IDO Recombinant Protein Cat. No.: 90-017

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psi-iconSpecifications
SPECIES:Mouse
SOURCE SPECIES:E. coli
SEQUENCE:Mouse IDO (aa 1-407) is fused at the C-terminus to a His-tag.
FUSION TAG:His Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Specific Activity: >100’000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.
psi-iconProperties
PURITY:>90% (SDS-PAGE).

Endotoxin level is less than 1EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Liquid
BUFFER:0.2um-filtered solution in 50mM TRIS-Cl, pH 7.4, containing 1mM EDTA.
CONCENTRATION:1mg/ml
STORAGE CONDITIONS:Working aliquots are stable for up to 3 months when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:Indoleamine 2,3-dioxygenase, INDO
ACCESSION NO.:P28776
PROTEIN GI NO.:123949
OFFICIAL SYMBOL:Ido1
GENE ID:15930
psi-iconBackground and References
BACKGROUND:IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.

FOR RESEARCH USE ONLY.

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