Human ACE2 Recombinant Protein Cat. No.: 10-421

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:Mammalian cells
SEQUENCE:Ser19-Asp615
FUSION TAG:C-His Tag
APPLICATIONS:Immunogen
BIOLOGICAL ACTIVITY: Testing in progress
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue Staining.
PREDICTED MOLECULAR WEIGHT:71.54kDa
PHYSICAL STATE:Lyophilized
BUFFER:Supplied as lyophilized from PBS, pH7.5
STORAGE CONDITIONS:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚C for one week. Store at -20 to -80 ˚C for twelve months from the date of receipt.
psi-iconAdditional Info
ALTERNATE NAMES:ACE-related carboxypeptidase Angiotensin-converting enzyme homolog Metalloprotease MPROT15
ACCESSION NO.:NP_001358344.1 or Q9BYF1
psi-iconBackground and References
BACKGROUND:Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

FOR RESEARCH USE ONLY.

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