HRSV Glycoprotein G Recombinant Protein Cat. No.: 97-054

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psi-iconSpecifications
SPECIES:Human cytomegalovirus
SOURCE SPECIES:HEK293 cells
SEQUENCE:His 67 - Arg 297
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:26.2 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:HRSV Glycoprotein G
ACCESSION NO.:P20895
OFFICIAL SYMBOL:Glycoprotein / GP (virus)
GENE ID:144411
psi-iconBackground and References
BACKGROUND:Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. Human respiratory syncytial virus A (strain Long) major surface glycoprotein G (RSV-G), a member of the pneumoviruses glycoprotein G family, is also known as attachment glycoprotein G and membrane-bound glycoprotein (mG), which contains a linear heparin binding domain essential for virus attachment to the host. Concretely speaking, RSV-G can attache the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Furthermore, RSV-G can also interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, RSV-G lacks both neuraminidase and hemagglutinating activities.
REFERENCES:1) Hendricks D.A., et al., 1986, J. Gen. Virol. 68:1705-1714.
2) Bao X., et al., 2008, PLoS Pathog. 4 (5): e1000077.

FOR RESEARCH USE ONLY.

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