Datasheet

HEPACAM2 Antibody
CATALOG NUMBER: 7111

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (95%)
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:HEPACAM2 antibody can be used for detection of HEPACAM2 by Western blot at 0.5 - 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1403 - Mouse Brain Tissue Lysate
PREDICTED MOLECULAR WEIGHT:51 kDa
SPECIFICITY:HEPACAM2 antibody is human, mouse and rat reactive. At least two isoforms of HEPACAM2 are known to exist; this antibody will detect both isoforms. HEPACAM2 antibody is predicted to not cross-react with HEPACAM.
IMMUNOGEN:Rabbit polyclonal HEPACAM2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human HEPACAM2.

The immunogen is located within amino acids 370 - 420 of HEPACAM2.
HOST SPECIES:Rabbit

Properties

PURIFICATION:HEPACAM2 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:HEPACAM2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:HEPACAM2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:HEPACAM2 Antibody: MIKI, MIKI, UNQ305/PRO346, HEPACAM family member 2, Mitotic kinetics regulator
ACCESSION NO.:NP_001034461
PROTEIN GI NO.:86439957
OFFICIAL SYMBOL:HEPACAM2
GENE ID:253012

Background

BACKGROUND:HEPACAM2 Antibody: HEPACAM2 (Hepatocyte cell adhesion molecule 2), a type I N-linked transmembrane glycoprotein, belongs to the immunoglobulin superfamily. The exact function of HEPACAM2 is currently unknown, but the related protein HEPACAM forms cishomodimers on the cell surface to regulate the cell adhesion and may inhibit cell growth through suppression of cell proliferation. HEPACAM and HEPACAM2 mRNA are differentially regulated in canine tumors, with HEPACAM2 mRNA showing increased levels in adenomas, but decreased levels in metastatic carcinomas compared to normal tissues, while HEPACAM protein levels decreased in adenomas. It is therefore likely that HEPACAM2 plays a different role than HEPACAM in the development and progression to tumors.
REFERENCES: 1) Klopfleisch R, Klose P, da Costa A, et al. HEPACAM1 and 2 are differentially regulated in canine mammary adenomas and carcinomas and its lymph nodes metastases. BMC Veterinary Res. 2010; 6:15.
2) Moh MC, Tian Q, Zhang T, et al. The immunoglobulin-like cell adhesion molecule HEPACAM modulate cell adhesion and motility through direct interaction with the actin cytoskeleton. J. Cell Physiol. 2009; 219:382-91.
3) Lee LH, Moh MC, Zhang T, et al. The immunoglobulin-like cell adhesion molecule HEPACAM induces differentiation of human glioblastoma U373-MG cells. J. Cell Biochem. 2009; 107:1129-38.

For Research Use Only