HDAC6 Antibody Cat. No.: 7901

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: HDAC6 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human HDAC6.

The immunogen is located within the last 50 amino acids of HDAC6.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: HDAC6 body can be used for detection of HDAC6 by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SPECIFICITY: HDAC6 antibody is human and mouse reactive. Multiple isoforms of HDAC6 are known to exist. HDAC6 antibody is predicted to not cross-react with other members of the HDAC family.
POSITIVE CONTROL:1) Cat. No. 1313 - Human Testis Tissue Lysate
 2) Cat. No. 11-701 - Human Testis Tissue Slide
PREDICTED MOLECULAR WEIGHT: Predicted: 55 kDa

Observed: 32 kDa

psi-iconProperties
PURIFICATION:HDAC6 antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:HDAC6 antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:HDAC6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:HDAC6
ALTERNATE NAMES:HDAC6 Antibody: HD6, JM21, CPBHM, KIAA0901, Histone deacetylase 6, HD6
ACCESSION NO.:NP_006035
PROTEIN GI NO.:13128864
GENE ID:10013
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class II of the HDAC family comprises six members, HDAC4, 5, 6, 7, 9 and 10, each of which appear to have tissue-specific roles (1). HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other (2). HDAC6 has been shown to be part of the microtubule network and acts as a specific alpha-tubulin deacetylase, and has been suggested to be a potential therapeutic target in neurodegenerative disease (3).
REFERENCES:1) de Ruijter AJ, van Gennip AH, Caron HN, et al. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J. 2003; 370:737-49.
2) Grozinger CM, Hassig CA, and Schrieber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. USA 1999; 96:4868-73.
3) Li G, Jiang H, Chang M, et al. HDAC6: a-tubulin decetylase: a potential therapeutic target in neurodegenerative disease. J. Neurol. Sci. 2011; 304:1-8.

ANTIBODIES FOR RESEARCH USE ONLY.

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