HCoV-229E Nucleocapsid Recombinant Protein Cat. No.: 11-163

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psi-iconSpecifications
SPECIES:HCoV-229E
SOURCE SPECIES:E. coli
SEQUENCE:Met 1 - Asn 389
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 44.4 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:44.4 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:Nucleocapsid protein,NP,Protein N,COVID-19
psi-iconBackground and References
BACKGROUND:Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.
REFERENCES:1) Reuter M, et al. Virus Genes. 2018. 54:5-16.
2) Grunewald ME, et al. Virology. 2018. 517:62-68.
3) Jeeva S, et al. PLoS One. 2017. 12(9):e0184935.

FOR RESEARCH USE ONLY.

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