HAVCR2 Recombinant Protein Cat. No.: 96-491

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Ser 22 - Glu 142
FUSION TAG:C-Fc Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
BIOLOGICAL ACTIVITY: Measured by its binding ability in a functional ELISA. Immobilized Human TIM-3, Fc Tag at 2μg/mL (100 μL/well) can bind Anti-TIM3 Mab, Human IgG4 with a linear range of 0.15-10 μg/mL.
psi-iconProperties
PURITY:>97% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:42 kDa
PHYSICAL STATE:Lyophilized
BUFFER:50 mM tris, 100 mM glycine, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:HAVCR2, TIM3, TIMD3, FLJ14428, KIM3
ACCESSION NO.:AAH20843
OFFICIAL SYMBOL:HAVCR2
GENE ID:84868
psi-iconBackground and References
BACKGROUND:Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,  KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
REFERENCES:1) Monney, L. et al., 2002, Nature. 415: 536-41.
2) Sabatos, CA. et al., 2003, Nat. Immunol. 4: 1102-10.
3) Anderson, AC. et al., 2006, Curr. Opin. Immunol. 18: 665-9.

FOR RESEARCH USE ONLY.

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