GSK-3a Antibody [SBGSK3a1] (HRP) Cat. No.: 99-741

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human, Mouse, Rat
TESTED APPLICATIONS: Activity, Complement Mediated Cell Depletion, Depletion, Flow, IHC, IP, WB
APPLICATIONS: GSK-3a Antibody [SBGSK3a1] for use in western blotting assays.
SPECIFICITY: GSK-3alpha

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2a
CONJUGATE:HRP
PHYSICAL STATE:Liquid
BUFFER:Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added
CONCENTRATION:Lot specific
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:GSK3A
ALTERNATE NAMES:Glycogen synthase kinase-3
ACCESSION NO.:P49840
GENE ID:2931
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3alpha and GSK-3beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.

ANTIBODIES FOR RESEARCH USE ONLY.

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