Datasheet

GRTP1 Antibody
CATALOG NUMBER: 4591

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:GRTP1 antibody can be used for detection of GRTP1 by Western blot at 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1220 - SK-N-SH Cell Lysate
SPECIFICITY:At least three isoforms of GRTP1 are known to exist; this antibody should recognize all isoforms.
IMMUNOGEN:GRTP1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human GRTP1.

The immunogen is located within amino acids 80 - 130 of GRTP1.
HOST SPECIES:Rabbit

Properties

PURIFICATION:GRTP1 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:GRTP1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:GRTP1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:GRTP1 Antibody: TBC1D6, TBC1D6, Growth hormone-regulated TBC protein 1, TBC1 domain family member 6
ACCESSION NO.:EAX09206
PROTEIN GI NO.:119629611
OFFICIAL SYMBOL:GRTP1
GENE ID:79774

Background

BACKGROUND:GRTP1 Antibody: Growth hormone regulated TBC protein 1 (GRTP1) was identified through microarray analysis as a gene whose expression is regulated by growth hormone (GH). It contains the TBC signature motif of GTPase activator proteins of Rab-like small GTPases. GRTP1 mRNA is expressed at highest levels in testes, and is also present in kidney, lung, liver, and intestine. Administration of GH to mice resulted in an increase in GRTP1 mRNA in testes, but a decrease of GRTP1 mRNA in kidney and liver. GRTP1 was identified as an HIV dependency factor (HDF), suggesting that GRTP1 may be an important drug target in HIV treatment.
REFERENCES: 1) Lu C, Kasik J, Stephan DA, et al. Grtp1, a novel gene regulated by growth hormone. Endocriniology2001; 142:4568-71.
2) Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science2008; 319:921-6.

For Research Use Only