Datasheet

Grik3 Antibody
CATALOG NUMBER: 4389

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:Grik3 antibody can be used for detection of Grik3 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate
IMMUNOGEN:Grik3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of the human Grik3.

The immunogen is located within amino acids 30 - 80 of Grik3.
HOST SPECIES:Rabbit

Properties

PURIFICATION:Grik3 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:Grik3 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Grik3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Grik3 Antibody: EAA5, GLR7, GLUR7, GluK3, GluR7a, Glutamate receptor ionotropic, kainate 3, Excitatory amino acid receptor 5
ACCESSION NO.:CAI19119
PROTEIN GI NO.:56205347
OFFICIAL SYMBOL:GRIK3
GENE ID:2899

Background

BACKGROUND:Grik3 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.
REFERENCES: 1) Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
2) Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
3) Puranam RS, Eubanks JH, Heinemann SF, et al. Chromosomal localization of gene for human glutamate receptor subunit-7. Somat. Cell Mol. Genet.1993; 19:581-8.
4) Pinheiro PS, Perrais D, Coussen F, et al. GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. USA2007; 104:12181-6.

For Research Use Only