Grik2 Antibody Cat. No.: 4387

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: Grik2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Grik2.

The immunogen is located within the last 50 amino acids of Grik2.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: Grik2 antibody can be used for detection of Grik2 by Western blot at 0.5 - 1 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate

psi-iconProperties
PURIFICATION:Grik2 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Grik2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Grik2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:GRIK2
ALTERNATE NAMES:Grik2 Antibody: EAA4, GLR6, MRT6, GLUK6, GLUR6, GluK2, Glutamate receptor ionotropic, kainate 2, Excitatory amino acid receptor 4
ACCESSION NO.:Q13002
PROTEIN GI NO.:2492627
GENE ID:2898
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Grik2 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Recent reports have suggested that defects in the Grik2 protein may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. This Grik2 antibody may exhibit some cross-reactivity to Grik3.
REFERENCES:1) Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
2) Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
3) Paschen W, Blackstone CD, Huganir RL, et al. Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment. Genomics1994; 20:435-40.
4) Motazacker MM, Rost BR, Hucho T, et al. A defect in the ionotrophic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation. Am. J. Hum. Genet.2007; 81:792-8.

ANTIBODIES FOR RESEARCH USE ONLY.

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