Grik1 Antibody Cat. No.: 4381

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: Grik1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human Grik1.

The immunogen is located within the last 50 amino acids of Grik1.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: Grik1 antibody can be used for detection of Grik1 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1286 - P815 Cell Lysate
 2) Cat. No. 10-301 - Human Brain Tissue Slide

psi-iconProperties
PURIFICATION:Grik1 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Grik1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Grik1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:GRIK1
ALTERNATE NAMES:Grik1 Antibody: EAA3, EEA3, GLR5, GLUR5, GluK1, Glutamate receptor ionotropic, kainate 1, Excitatory amino acid receptor 3
ACCESSION NO.:P39086
PROTEIN GI NO.:729597
GENE ID:2897
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Grik1 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
REFERENCES:1) Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
2) Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
3) Bureau I, Dieudonne S, Coussen F, et al. Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice. J. Neurosci.1999; 19:653-63.
4) Christensen JK, Paternain AV, Selak S, et al. A mosaic of functional kainate receptors in hippocampal interneurons. J. Neurosci.2004; 24:8986-93.

ANTIBODIES FOR RESEARCH USE ONLY.

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