GPR15 Antibody Cat. No.: 2101

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: GPR15 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human GPR15.

The immunogen is located within the first 50 amino acids of GPR15.
TESTED APPLICATIONS: ELISA, ICC, WB
APPLICATIONS: GPR15 antibody can be used for detection of GPR15 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1205 - Jurkat Cell Lysate
 2) Cat. No. 1203 - A549 Cell Lysate
PREDICTED MOLECULAR WEIGHT: Predicted: 40 kDa

Observed: 49 kDa

psi-iconProperties
PURIFICATION:GPR15 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:GPR15 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:GPR15 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:GPR15
ALTERNATE NAMES:GPR15 Antibody: BOB
ACCESSION NO.:U34806
PROTEIN GI NO.:1171145
GENE ID:2838
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:GPR15 Antibody: Human immunodeficiency virus (HIV) and related viruses require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four other molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. GPR15, also known as BOB, is a G protein-coupled receptor that serves as coreceptor for the simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1.
REFERENCES:1) Heiber M, Marchese A, Nguyen T, et al. A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3. Genomics 1996; 32:462-5
2) Deng HK, Unutmaz D, KewalRamani VN, et al. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997; 388:296-300
3) Farzan M, Choe H, Martin K, et al. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J. Exp. Med. 1997;186:405-11.

ANTIBODIES FOR RESEARCH USE ONLY.

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