This recombinant protein can be used for E, WB. For research use only.
BIOLOGICAL ACTIVITY:
Measured by its binding ability in a functional ELISA. Immobilized Human FGF basic, Tag Free at 2 ug/mL (100 uL/well) can bind Cynomolgus Glypican 3, Fc Tag with a linear range of 4.8-19.5 ng/mL (QC tested).
Properties
PURITY:
>90% as determined by SDS-PAGE
PREDICTED MOLECULAR WEIGHT:
38.1 kDa and 49.4 kDa
PHYSICAL STATE:
Lyophilized
BUFFER:
Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.
REFERENCES:
1) Davoodi J., et al., 2007, Proteomics 7:2300-2310.
2) Veugelers M., et al., 2000, Hum. Mol. Genet. 9:1321-1328.
Specifications
