Datasheet

GLIPR1 Antibody
CATALOG NUMBER: 7623

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
TESTED APPLICATIONS:ELISA, IF, WB
APPLICATIONS:GLIPR1 antibody can be used for detection of GLIPR1 by Western blot at 1 - 2 μg/ml. For Immunoflorescence start at 5 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1308 - Human Small Intestine Tissue Lysate
 2) Cat. No. 11-801 - Human Small Intestine Tissue Slide
PREDICTED MOLECULAR WEIGHT:Predicted: 29 kDa

Observed: 29 kDa
SPECIFICITY:GLIPR1 antibody is human and mouse reactive. At least two isoforms of GLIPR1 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.
IMMUNOGEN:GLIPR1 antibody was raised against an 18 amino acid peptide near the center of human GLIPR1.

The immunogen is located within amino acids 60 - 110 of GLIPR1.
HOST SPECIES:Rabbit

Properties

PURIFICATION:GLIPR1 antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:GLIPR1 antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:GLIPR1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:GLIPR1 Antibody: GLIPR, RTVP1, CRISP7, GLIPR, Glioma pathogenesis-related protein 1, Protein RTVP-1, GliPR 1
ACCESSION NO.:NP_006842
PROTEIN GI NO.:110825980
OFFICIAL SYMBOL:GLIPR1
GENE ID:11010

Background

BACKGROUND:The glioma pathogensis-related protein 1 (GLIPR1) is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (1). GLIPR1 is a tumor suppressor whose expression is regulated by p53; its increased expression is associated with myelomocytic differentiation in macrophages, whereas decreased expression of this gene through gene methylation is associated with prostate cancer (2). The GLIPR1 gene is part of a p53 target gene cluster that includes GLIPR1L1 and GLIPR1L2, two highly homologous proteins whose expression patterns vary (3).
REFERENCES: 1) Murphy EV, Zhang Y, Zhu W, et al. The human glioma pathogenesis-related protein is structurally related to pathogenesis-related proteins and its gene is expressed specifically in brain tumors. Gene 1995; 159:131-5.
2) Ren C, Li L, Yang G, et al. RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res. 2004; 64:969-76.
3) Ren C, Ren CH, Li L, et al. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Genomics 2006; 88:163-72.

For Research Use Only