GLI3 Antibody Cat. No.: 49-600

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Chicken, Chimpanzee, Dog, Human, Squirrel monkey, Xenopus
IMMUNOGEN: GLI3 antibody was raised against amino acids 41-57 of GLI3 (Human).
TESTED APPLICATIONS: ELISA, IHC, WB
APPLICATIONS: GLI3 antibody can be used in immunohistochemistry starting at 5 μg/mL, and immunofluorescence.

psi-iconProperties
PURIFICATION:Immunoaffinity Chromatography
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.1% sodium azide.
CONCENTRATION:1 mg/ml
STORAGE CONDITIONS:Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:GLI3
ALTERNATE NAMES:GLI3, ACLS, GCPS, GLI-Kruppel family member GLI3, GLI3 full length protein, GLI3-190, GLI family zinc finger 3, Gli-3, GLI3FL, PAP-A, PAPA1, PHS, PPDIV, Transcriptional activator GLI3, PAPA, PAPB, GLI3 form of 190 kDa, Oncogene GLI3, Zinc finger protein GLI3
ACCESSION NO.:P10071
PROTEIN GI NO.:269849770
GENE ID:2737
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Gli-3 (also known as Zinc Finger Protein Gli-3 or GLI-Kruppel family member GLI-3) belongs to the GLI C2H2-type zinc-finger protein family and contains 5 C2H2-type zinc fingers. Gli-3 is very important for normal limb and brain development and is implicated in the transduction of Shh signal. Gli-3 is a nuclear protein expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium. Defects in Gli-3 are the cause of Greig cephalo-poly-syndactyly syndrome (GCPS); an autosomal dominant disorder-affecting limb and cranio-facial development. Two isoforms of human Gli-3 have been reported. One is the full-length protein at ~170-190 kDa and the other is a truncated isoform at ~80 kDa.

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