Specifications
| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: |
Chicken, Chimpanzee, Dog, Human, Squirrel monkey, Xenopus |
| IMMUNOGEN: |
GLI3 antibody was raised against amino acids 41-57 of GLI3 (Human). |
| TESTED APPLICATIONS: |
ELISA, IHC, WB |
| APPLICATIONS: |
GLI3 antibody can be used in immunohistochemistry starting at 5 μg/mL, and immunofluorescence. |
Properties
| PURIFICATION: | Immunoaffinity Chromatography |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.1% sodium azide. |
| CONCENTRATION: | 1 mg/ml |
| STORAGE CONDITIONS: | Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles. |
Additional Info
| OFFICIAL SYMBOL: | GLI3 |
| ALTERNATE NAMES: | GLI3, ACLS, GCPS, GLI-Kruppel family member GLI3, GLI3 full length protein, GLI3-190, GLI family zinc finger 3, Gli-3, GLI3FL, PAP-A, PAPA1, PHS, PPDIV, Transcriptional activator GLI3, PAPA, PAPB, GLI3 form of 190 kDa, Oncogene GLI3, Zinc finger protein GLI3 |
| ACCESSION NO.: | P10071 |
| PROTEIN GI NO.: | 269849770 |
| GENE ID: | 2737 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
Background and References
| BACKGROUND: | Gli-3 (also known as Zinc Finger Protein Gli-3 or GLI-Kruppel family member GLI-3) belongs to the GLI C2H2-type zinc-finger protein family and contains 5 C2H2-type zinc fingers. Gli-3 is very important for normal limb and brain development and is implicated in the transduction of Shh signal. Gli-3 is a nuclear protein expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium. Defects in Gli-3 are the cause of Greig cephalo-poly-syndactyly syndrome (GCPS); an autosomal dominant disorder-affecting limb and cranio-facial development. Two isoforms of human Gli-3 have been reported. One is the full-length protein at ~170-190 kDa and the other is a truncated isoform at ~80 kDa. |
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