GDPD5 Antibody Cat. No.: 7739

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chicken: (94%)
IMMUNOGEN: GDPD5 antibody was raised against an 18 amino acid peptide near the amino terminus of human GDPD5.

The immunogen is located within the first 50 amino acids of GDPD5.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: GDPD5 antibody can be used for detection of GDPD5 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SPECIFICITY: GDPD5 antibody is human, mouse and rat reactive. At least three isoforms of GDPD5 are known to exist.
POSITIVE CONTROL:1) Cat. No. 1405 - Mouse Kidney Tissue Lysate
 2) Cat. No. 10-401 - Human Kidney Tissue Slide
PREDICTED MOLECULAR WEIGHT: Predicted: 40, 67 kDa

Observed: 52 kDa

psi-iconProperties
PURIFICATION:GDPD5 antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:GDPD5 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:GDPD5 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:GDPD5
ALTERNATE NAMES:GDPD5 Antibody: GDE2, PP1665, GDE2, PP6037, PP9363, UNQ1850/PRO3580, Glycerophosphodiester phosphodiesterase domain-containing protein 5, Glycerophosphodiester phosphodiesterase 2
ACCESSION NO.:NP_110419
PROTEIN GI NO.:189571657
GENE ID:81544
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) protein, also known as GDE2, is a seven transmembrane, widely expressed protein (1) that is necessary for spinal motor neuron differentiation and retinoid-induced neuronal outgrowth (2,3). Altered choline phospholipid metabolism is a hallmark of cancer, and the elevated expression of GDPD5 correlates with malignant choline phospholipid metabolite profiles in human breast cancer (4).
REFERENCES:1) Nogusa Y, Fujioka Y, Komatsu R, et al. Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6. Gene 2004; 337:173-9.
2) Rao M and Sockanathan S. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science 2005; 309:2212-5.
3) Yanaka N, Nogusa Y, Fujioka Y, et al. Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells. FEBS Lett. 2007; 581:712-8.
4) Cao MD, Dopkens M, Krishnamachary B, et al. Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR Biomed. 2012; 25:1033-42.

ANTIBODIES FOR RESEARCH USE ONLY.

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