Datasheet

GDF6 Antibody
CATALOG NUMBER: 4691

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (100%)
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:GDF6 antibody can be used for detection of GDF6 by Western blot at 0.5 to 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1220 - SK-N-SH Cell Lysate
IMMUNOGEN:GDF6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human GDF6.

The immunogen is located within amino acids 320 - 370 of GDF6.
HOST SPECIES:Rabbit

Properties

PURIFICATION:GDF6 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:GDF6 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:GDF6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:GDF6 Antibody: KFM, KFS, KFS1, KFSL, SGM1, BMP13, CDMP2, LCA17, MCOP4, SCDO4, MCOPCB6, GDF16GDF-6
ACCESSION NO.:NP_001001557
PROTEIN GI NO.:48475062
OFFICIAL SYMBOL:GDF6
GENE ID:392255

Background

BACKGROUND:GDF6 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
REFERENCES: 1) Massague J. 1990. The transforming growth factor-beta family. Ann. Rev. Cell Biol.6:597-641.
2) McPherron AC, Lawler AM, and Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature1997; 387:83-90.
3) Hanel ML and Hensey C. Eye and neural defects associated with loss of GDF6. BMC Dev. Biol.2006; 6:43.
4) Settle SH Jr., Rountree RB, Sinha A, et al. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev. Biol.2003; 254:116-130.

For Research Use Only