| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| IMMUNOGEN: | Rabbit polyclonal GDF1 antibody was raised against a 16 amino acid peptide near the amino terminus of human GDF1. The immunogen is located within amino acids 30 - 80 of GDF1. |
| TESTED APPLICATIONS: | ELISA, IF, WB |
| APPLICATIONS: | GDF1 antibody can be used for detection of GDF1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested. |
| SPECIFICITY: | GDF1 antibody is predicted to not cross-react with any other members of the growth differentiation factor family. |
| POSITIVE CONTROL: | 1) Cat. No. 1462 - Rat Lung Tissue Lysate |
| 2) Cat. No. 10-101 - Human Lung Tissue Slide | |
| PREDICTED MOLECULAR WEIGHT: | 41 kDa |
Specifications| PURIFICATION: | GDF1 Antibody is affinity chromatography purified via peptide column. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | GDF1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | GDF1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| OFFICIAL SYMBOL: | GDF1 |
| ALTERNATE NAMES: | GDF1 Antibody: RAI, DORV, DTGA3GDF-1 |
| ACCESSION NO.: | NP_001483 |
| PROTEIN GI NO.: | 110349792 |
| GENE ID: | 2657 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | GDF1 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. GDF1 was initially identified as a temporally expressed gene in the mouse central nervous system during embryonic development, with only one isoform detected in adult tissues. GDF1 is required for left-right patterning during development and directly interacts with Nodal, another member of the TGF-beta superfamily. It has been suggested that GDF1 regulates the activity and signaling range of Nodal through direct interaction. |
| REFERENCES: | 1) Massague J. 1990. The transforming growth factor-beta family. Ann. Rev. Cell Biol. 6:597-641. | 2) Lee SJ. Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. Proc. Natl. Acad. Sci. USA 1991; 88:4250-4. | 3) Rankin CT, Bunton T, Lawler AM, et al. Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat. Genet. 2000; 24:262-5. | 4) Tanaka C, Sakuma R, Nakamura T, et al. Long-range action of Nodal requires interaction with GDF1. Genes Dev. 2007; 21:3272-82. |
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