GCN5 highly active Recombinant Protein Cat. No.: 90-345

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:Sf21 cells
SEQUENCE:Human GCN5 is fused to a His-tag.
FUSION TAG:His Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: ~200-300ng are required for standard HAT assay.
psi-iconProperties
PURITY:>95% (SDS-PAGE)
PHYSICAL STATE:Liquid
BUFFER:In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
CONCENTRATION:Lot dependent (0.2-0.5mg/ml)
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -80˚C.
psi-iconAdditional Info
ALTERNATE NAMES:GCN5L2, Histone Acetyltransferase GCN5, Histone Acetyltransferase KAT2A, Lysine Acetyltransferase 2A, STAF97
ACCESSION NO.:Q92830
PROTEIN GI NO.:209572743
OFFICIAL SYMBOL:KAT2A
GENE ID:2648
psi-iconBackground and References
BACKGROUND:GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4.

FOR RESEARCH USE ONLY.

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