Datasheet

GBP5 Antibody
CATALOG NUMBER: 7327

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:GBP5 Antibody can be used for detection of GBP5 by Western blot at 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1464 - Rat Liver Tissue Lysate
 2) Cat. No. 10-201 - Human Liver Tissue Slide
PREDICTED MOLECULAR WEIGHT:Predicted: 64 kDa

Observed: 66 kDa
SPECIFICITY:GBP5 antibody is predicted to not cross-react with other GBP family members.
IMMUNOGEN:GBP5 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human GBP5 .

The immunogen is located within the last 50 amino acids of GBP5.
HOST SPECIES:Rabbit

Properties

PURIFICATION:GBP5 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:GBP5 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:GBP5 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:GBP5 Antibody: GBP-5, Guanylate-binding protein 5, GBP-TA antigen, GBP-5
ACCESSION NO.:NP_443174
PROTEIN GI NO.:16418425
OFFICIAL SYMBOL:GBP5
GENE ID:115362

Background

BACKGROUND:GBP5 Antibody: The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN). GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.
REFERENCES: 1) Vestal DJ. The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. J. Interferon Cytokine Res. 2005; 25:435-43.
2) Kresse A, Konermann C, Degrandi D, et al. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 2008; 9:158.
3) Hammon M, Herrmann M, Bleiziffer O, et al. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J. Cell Mol. Med. 2011; 15:1582-92.
4) Shenoy AR, Wellington DA, Kumar P, et al. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 2012; 336:481-5.

For Research Use Only