gAcrp30 Recombinant Protein Cat. No.: 40-487

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psi-iconSpecifications
SPECIES:Murine
SOURCE SPECIES:E. coli
SEQUENCE:MKGEPGEAAY MYRSAFSVGL ETRVTVPNVP IRFTKIFYNQ QNHYDGSTGK FYCNIPGLYY FSYHITVYMK DVKVSLFKKD KAVLFTYDQY QEKNVDQASG SVLLHLEVGD QVWLQVYGDG DHNGLYADNV NDSTFTGFLL YHDTN
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: Biological activity was determined by its ability to inhibit the proliferation of murine myeloid cell lines M1. The ED50 for this effect is < 15 μg/mL.
psi-iconProperties
PURITY:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized gAcrp30 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted gAcrp30 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing gAcrp30 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:APN, Acdc, apM1, 30kDa, GBP28, adipo, Acrp30, Apm1, Adiponectin, 30 kDa adipocyte complement-related protein, ACRP30
ACCESSION NO.:NP_033735.3
PROTEIN GI NO.:87252711
OFFICIAL SYMBOL:Adipoq
GENE ID:11450
psi-iconBackground and References
BACKGROUND:gAcrp30 is a naturally occurring globular protein, obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, gAcrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and names AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver. Recombinant murine gAcrp30 is a 16.6 kDa protein consisting of 145 amino acid residues.

FOR RESEARCH USE ONLY.

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