GABAB Receptor (phospho Ser923) Antibody Cat. No.: 50-227

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Bovine, Human, Mouse, Rat
IMMUNOGEN: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser923 of GABAB R1.
TESTED APPLICATIONS: WB
APPLICATIONS: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
PREDICTED MOLECULAR WEIGHT: 102

psi-iconProperties
PURIFICATION:Affinity Purified
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
STORAGE CONDITIONS:GABAB Receptor antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

psi-iconAdditional Info
OFFICIAL SYMBOL:Gabbr1
ALTERNATE NAMES:GABA-B receptor 1
ACCESSION NO.:Q9Z0U4
PROTEIN GI NO.:12643494
GENE ID:81657
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function.
REFERENCES:1) Couve A, Calver AR, Fairfax B, Moss SJ, Pangalos MN (2004) Unravelling the unusual signaling proerties of the GABA(B) receptor. Biochem. Pharmacol. Oct 12;68(8):1527-36.

ANTIBODIES FOR RESEARCH USE ONLY.

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