Furin Recombinant Protein Cat. No.: 40-542

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:High-5 Insect cells
SEQUENCE:DLNVKAAWAQ GYTGHGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC TESHTGTSAS APLAAGIIAL TLEANKNLTW RDMQHLVVQT SKPAHLNAND WATNGVGRKV SHSYGYGLLD AGAMVALAQN WTTVAPQRKC IIDILTEPKD IGKRLEVRKT VTACLGEPNH ITRLEHAQAR LTLSYNRRGD LAIHLVSPMG TRSTLLAARP HDYSADGFND WAFMTTHSWD EDPSGEWVLE IENTSEANNY GTLTKFTLVL YGTAPEGLPV PPESSGCKTL TSSQACVVCE EGFSLHQKSC VQHCPPGFAP QVLDTHYSTE NDVETIRASV CAPC
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: Biological activity was measured by its ability to cleave the fluorogenic peptide substrate Boc-Arg-Val-Arg-Arg-AMC (Bachem Catalog# I-1645.0025). Endotoxin level is less than 0.1 ng per μg (1EU/μg).
psi-iconProperties
PURITY:Greater than 95% by SDS-PAGE gel and HPLC analyses.
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized Furin recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Furin stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Furin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:FUR, PACE, SPC1, PCSK3, FUR, Furin, Dibasic-processing enzyme
ACCESSION NO.:NP_001276752.1
PROTEIN GI NO.:577019578
OFFICIAL SYMBOL:FURIN
GENE ID:5045
psi-iconBackground and References
BACKGROUND:Proteases (also called Proteolytic Enzymes, Peptidases, or Proteinases) are enzymes that hydrolyze the amide bonds within proteins or peptides. Most proteases act in a specific manner, hydrolyzing bonds at or adjacent to specific residues or a specific sequence of residues contained within the substrate protein or peptide. Proteases play an important role in most diseases and biological processes including prenatal and postnatal development, reproduction, signal transduction, the immune response, various autoimmune and degenerative diseases, and cancer. They are also an important research tool, frequently used in the analysis and production of proteins. Furin is a calcium dependent serine endoprotease that processes numerous proproteins of different secretory pathways into their mature forms by cleaving at the carboxyl side of the recognition sequence, R-Xaa-(K/R)-R, where Xaa can be any amino acid. Recombinant human Furin is a 63.9 kDa protein, corresponding to residues 131 through 715 of the Furin precursor plus a C-terminal His tag.

FOR RESEARCH USE ONLY.

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