Datasheet

FRMPD3 Antibody
CATALOG NUMBER: 5457

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:FRMPD3 antibody can be used for detection of FRMPD3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1205 - Jurkat Cell Lysate
 2) Cat. No. 10-301 - Human Brain Tissue Slide
IMMUNOGEN:FRMPD3 antibody was raised against an 18 amino acid synthetic peptide from near the center of human FRMPD3.

The immunogen is located within amino acids 690 - 740 of FRMPD3.
HOST SPECIES:Rabbit

Properties

PURIFICATION:FRMPD3 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:FRMPD3 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:FRMPD3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:FRMPD3 Antibody: KIAA1817, FERM and PDZ domain-containing protein 3
ACCESSION NO.:Q5JV73
PROTEIN GI NO.:118582027
OFFICIAL SYMBOL:FRMPD3
GENE ID:84443

Background

BACKGROUND:FRMPD3 Antibody: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. Unlike other members of the FRMPD family, FRMPD3 has no known function. It is most similar to FRMPD4, which is highly expressed in multiple regions of the brain and enriched in the postsynaptic density (PSD) fractions, it is possible that FRMPD3 also interacts with other PDZ domain-containing proteins in neural cells.
REFERENCES: 1) An N, Blumer JB, Bernard ML. The PDZ and Band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. J. Biol. Chem.2008; 283:24718-28.
2) Stenzel N, Fetzer CP, Heumann R, et al. PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. J. Cell Sci.2009; 122:3374-84.
3) Lee HW, Choi J, Shin H, et al. Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. J. Neurosci.2008; 28:14546-56.

For Research Use Only