FOXRED2 Antibody Cat. No.: 6761

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (94%)
IMMUNOGEN: FOXRED2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human FOXRED2.

The immunogen is located within amino acids 70 - 120 of FOXRED2.
TESTED APPLICATIONS: ELISA, IF, WB
APPLICATIONS: FOXRED2 antibody can be used for detection of FOXRED2 by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1302 - Human Lung Tissue Lysate

psi-iconProperties
PURIFICATION:FOXRED2 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:FOXRED2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:FOXRED2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:FOXRED2
ALTERNATE NAMES:FOXRED2 Antibody: ERFAD, ERFAD, FAD-dependent oxidoreductase domain-containing protein 2, Endoplasmic reticulum flavoprotein associated with degradation
ACCESSION NO.:No. Q8IWF2
PROTEIN GI NO.:156139139
GENE ID:80020
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:FOXRED2 Antibody: FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD). It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.
REFERENCES:1) Riemer J, Appenzeller-Herzog C, Johansson L, et al. A luminal flavoprotein in endoplasmic reticulum-associated degradation. Proc. Natl. Acad. Sci. USA 2009; 106:14831-6.
2) Riemer J, Hansen HG, Appenzeller-Herzog C, et al. Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. PLoS One 2011; 6:e17037
3) Calvo SE, Tucker EJ, Compton AG, et al. High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nat. Genet. 2010; 42:851-8.

ANTIBODIES FOR RESEARCH USE ONLY.

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