FOLR1 Recombinant Protein Cat. No.: 96-795

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psi-iconSpecifications
SPECIES:Cynomolgus, Rhesus macaque
SOURCE SPECIES:HEK293 cells
SEQUENCE:Arg 25 - Met 233
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This recombinant protein can be used for E, WB. For research use only.
BIOLOGICAL ACTIVITY: Measured by its binding ability in a functional ELISA. Immobilized Folic acid-BSA conjugate at 20 ug/mL (100 uL/well) can bind Cynomolgus / Rhesus macaque FOLR1, His Tag with a linear range of 0.156-2.5 ug/mL (QC tested).
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:26.4 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:FOLR-1,FBP,FOLR
ACCESSION NO.:NP_001181576.1
OFFICIAL SYMBOL:FOLR1
GENE ID:718388
psi-iconBackground and References
BACKGROUND:Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
REFERENCES:1) Lacey SW, et al., 1989, J. Clin. Invest. 84 (2): 715–20.
2) Elwood PC, 1989, J. Biol. Chem. 264 (25): 14893–901.
3) Rijnboutt, S. et al., 1996, J. Cell Biol. 132:35.
4) Parker, N. et al., 2005, Anal. Biochem. 338:284.

FOR RESEARCH USE ONLY.

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