Datasheet

FCHSD1 Antibody
CATALOG NUMBER: 6509

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:FCHSD1 antibody can be used for detection of FCHSD1 by Western blot at 0.5 - 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1219 - MCF7 Cell Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 76 kDa

Observed: 82 kDa
SPECIFICITY:Multiple isoforms of FCHSD1 are known to exist. FCHSD1 antibody is predicted to not cross-react with FCHSD2
IMMUNOGEN:FCHSD1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human FCHSD1.

The immunogen is located within the last 50 amino acids of FCHSD1.
HOST SPECIES:Chicken

Properties

PURIFICATION:FCHSD1 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:FCHSD1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:FCHSD1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgY
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:FCHSD1 Antibody: NWK2, FCH and double SH3 domains protein 1
ACCESSION NO.:NP_258260
PROTEIN GI NO.:28875786
OFFICIAL SYMBOL:FCHSD1
GENE ID:89848

Background

BACKGROUND:FCHSD1 Antibody: The FCH and double SH3 domains protein 1 (FCHSD1, also known as NWK2) and the related protein FCHSD2 were initially identified in silico as distantly related proteins to FNBP1 and FNBP2. Both share the common domain structure consisting of FCH, FBH, two SH3 and C-terminal proline-rich domains. While little is known of the function of FCHSD1, the related protein NWK is an adaptor protein that is thought to regulate Rho activity downstream of Robo receptors, suggesting that FCHSD1 may be involved in synaptic morphology by regulating actin dynamics in presynaptic terminals.
REFERENCES: 1) Kato M and Kato M. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. Int. J. Mol. Med. 2004; 13:749-54.
2) Coyle IP, Koh YH, Lee WC, et al. Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in drosophila. Neuron 2004; 41:521-34

For Research Use Only