FCHSD1 Antibody Cat. No.: 6509

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psi-iconSpecifications
HOST SPECIES:Chicken
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: FCHSD1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human FCHSD1.

The immunogen is located within the last 50 amino acids of FCHSD1.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: FCHSD1 antibody can be used for detection of FCHSD1 by Western blot at 0.5 - 1 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
SPECIFICITY: Multiple isoforms of FCHSD1 are known to exist. FCHSD1 antibody is predicted to not cross-react with FCHSD2
POSITIVE CONTROL:1) Cat. No. 1219 - MCF7 Cell Lysate
PREDICTED MOLECULAR WEIGHT: Predicted: 76 kDa

Observed: 82 kDa

psi-iconProperties
PURIFICATION:FCHSD1 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgY
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:FCHSD1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:FCHSD1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:FCHSD1
ALTERNATE NAMES:FCHSD1 Antibody: NWK2, FCH and double SH3 domains protein 1
ACCESSION NO.:NP_258260
PROTEIN GI NO.:28875786
GENE ID:89848
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:FCHSD1 Antibody: The FCH and double SH3 domains protein 1 (FCHSD1, also known as NWK2) and the related protein FCHSD2 were initially identified in silico as distantly related proteins to FNBP1 and FNBP2. Both share the common domain structure consisting of FCH, FBH, two SH3 and C-terminal proline-rich domains. While little is known of the function of FCHSD1, the related protein NWK is an adaptor protein that is thought to regulate Rho activity downstream of Robo receptors, suggesting that FCHSD1 may be involved in synaptic morphology by regulating actin dynamics in presynaptic terminals.
REFERENCES:1) Kato M and Kato M. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. Int. J. Mol. Med. 2004; 13:749-54.
2) Coyle IP, Koh YH, Lee WC, et al. Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in drosophila. Neuron 2004; 41:521-34

ANTIBODIES FOR RESEARCH USE ONLY.

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