| SPECIES: | Human, Mouse |
| SOURCE SPECIES: | HEK293 cells |
| SEQUENCE: | Human FasL (aa 139-281) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a DDDDK-tag. |
| FUSION TAG: | DDDDK Tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant proteins is for research use only. |
| BIOLOGICAL ACTIVITY: | Induces apoptosis of human Jurkat T cells at a concentration of <0.2ng/ml. |
Specifications| PURITY: | >95% (SDS-PAGE). Endotoxin level is less than 0.02EU/ μg purified protein (LAL test; Lonza). |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Contains PBS. Reconstitute with 100 μl sterile water. |
| CONCENTRATION: | 0.1mg/ml after reconstitution. |
| STORAGE CONDITIONS: | Stable for at least 6 months after receipt when stored at -20˚C. |
| ALTERNATE NAMES: | MegaFasL, ACRP30headless:APO-1L, ACRP30headless:CD95L, ACRP30headless:CD178, ACRP30headless:TNFSF6, ACRP30headless:Fas Ligand |
| ACCESSION NO.: | P48023 |
| PROTEIN GI NO.: | 4557329 |
| OFFICIAL SYMBOL: | FASLG |
| GENE ID: | 356 |
| BACKGROUND: | MultimericFasL™ is a high activity construct in which two trimeric FasL are artificially linked via the collagen domain of ACRP30. This construct very effectively mimics the natural membrane-assisted aggregation of FasL in vivo. FasL is a cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. It is involved in cytotoxic T cell mediated apoptosis and in T cell development. |
FOR RESEARCH USE ONLY.
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