FasL multimeric Recombinant Protein Cat. No.: 90-310

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psi-iconSpecifications
SPECIES:Human, Mouse
SOURCE SPECIES:HEK293 cells
SEQUENCE:Human FasL (aa 139-281) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a DDDDK-tag.
FUSION TAG:DDDDK Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Induces apoptosis of human Jurkat T cells at a concentration of <0.2ng/ml.
psi-iconProperties
PURITY:>95% (SDS-PAGE).

Endotoxin level is less than 0.02EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Contains PBS. Reconstitute with 100 μl sterile water.
CONCENTRATION:0.1mg/ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:MegaFasL, ACRP30headless:APO-1L, ACRP30headless:CD95L, ACRP30headless:CD178, ACRP30headless:TNFSF6, ACRP30headless:Fas Ligand
ACCESSION NO.:P48023
PROTEIN GI NO.:4557329
OFFICIAL SYMBOL:FASLG
GENE ID:356
psi-iconBackground and References
BACKGROUND:MultimericFasLâ„¢ is a high activity construct in which two trimeric FasL are artificially linked via the collagen domain of ACRP30. This construct very effectively mimics the natural membrane-assisted aggregation of FasL in vivo. FasL is a cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. It is involved in cytotoxic T cell mediated apoptosis and in T cell development.

FOR RESEARCH USE ONLY.

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