Fas Ligand Antibody [SB93a] Cat. No.: 99-786

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Chicken, Human
IMMUNOGEN: Recombinant human Fas ligand
TESTED APPLICATIONS: ELISA, IHC-Fr
APPLICATIONS: Fas Ligand Antibody [SB93a] for use in flow cytometry, immunohistochemistry, western blotting, and immunoprecipitation assays.
SPECIFICITY: Fas Ligand

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2b
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
CONCENTRATION:0.5 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:FASLG
ALTERNATE NAMES:FasL, CD178, CD95L, TNFSF6
ACCESSION NO.:P48023
GENE ID:356
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Fas ligand (CD178) is a 40 kD type II transmembrane protein that is a member of the tumor necrosis factor superfamily. This well characterized potent apoptotic factor is utilized by cytotoxic T cells and natural killer cells to selectively kill virus infected and tumorigenic cells. Moreover, studies indicate that Fas ligand is an important regulator in immune homeostasis where it has been shown to down-regulate immune responses during activation-induced cell death. Fas ligand initiates apoptosis by binding to its receptor, CD95, on target cells which facilitates recruitment of numerous signaling proteins to form a death inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8. The SB93a monoclonal antibody detects a band at ~40 kDa corresponding to the transmembrane/insoluble form of Fas ligand.

ANTIBODIES FOR RESEARCH USE ONLY.

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