Datasheet

FAM59B Antibody
CATALOG NUMBER: 5481

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:FAM59B antibody can be used for detection of FAM59B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1220 - SK-N-SH Cell Lysate
 2) Cat. No. 10-301 - Human Brain Tissue Slide
IMMUNOGEN:FAM59B antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FAM59B.

The immunogen is located within amino acids 600 - 650 of FAM59B.
HOST SPECIES:Rabbit

Properties

PURIFICATION:FAM59B Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:FAM59B Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:FAM59B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:FAM59B Antibody: FAM59B, FAM59B, KIAA2038, HRIHFB2063, GRB2-associated and regulator of MAPK protein-like, GRB2-associated and regulator of MAPK1-like
ACCESSION NO.:Q75VX8
PROTEIN GI NO.:190359325
OFFICIAL SYMBOL:FAM59B
GENE ID:150946

Background

BACKGROUND:FAM59B Antibody: FAM59B is related to the FAM59A protein (also known as GAREM). While little is known of the role of the FAM59B protein, FAM59A is a downstream molecule in the EGF signaling pathway and binds Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. Like FAM59A, FAM59B may play a role in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.
REFERENCES: 1) Blagoev B, Ong SE, Kratchmarova I, et al. Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nat. Biotechnol.2004; 22:1139-45.
2) Tashiro K, Tsunematsu T, Okubo H, et al. GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through activation of extracellular signal-regulated kinase signaling. J. Biol. Chem.2009; 284:20206-14.

For Research Use Only