Datasheet

FAM212A Antibody
CATALOG NUMBER: 5531

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:FAM212A antibody can be used for detection of FAM212A by Western blot at 1 - 2 μg/ml.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1287 - EL4 Cell Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 32 kDa

Observed: 33 kDa
SPECIFICITY:FAM212A antibody is human and mouse . At least two isoforms of FAM212A are known to exist; this antibody will recognize both isoforms.
IMMUNOGEN:FAM212A antibody was raised against a 15 amino acid peptide near the carboxy terminus of human FAM212A.

The immunogen is located within the last 50 amino acids of FAM212A.
HOST SPECIES:Rabbit

Properties

PURIFICATION:FAM212A antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:FAM212A antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:FAM212A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Family with sequence similarity 212 member A, INKA1, C3orf54
ACCESSION NO.:NP_976248
PROTEIN GI NO.:42766424
OFFICIAL SYMBOL:FAM212A
GENE ID:389119

Background

BACKGROUND:FAM212A, initially identified as INCA (induced in neural crest by AP-2alpha) in xenopus, is expressed primarily in neural crest cells and their derivatives (1). FAM212A can associate with the P21-kinase protein PAK4 and this association modulates cytoskeletal dynamics (1). In mammals, FAM212A is thought to play a role in neural tube closure; a significant fraction of FAM212A-null mice exhibited exencephaly (2).
REFERENCES: 1) Luo T, Xu Y, Hoffman TL, et al. Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development. Dev. 2007; 134:1279-89.
2) Reid BS, Sargent TD, and Willams T. Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure. Dev. Dyn. 2010; 239:1188-96.

For Research Use Only