Datasheet

FAM193B Antibody
CATALOG NUMBER: 6941

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (81%)
TESTED APPLICATIONS:ELISA, IF, WB
APPLICATIONS:FAM193B antibody can be used for detection of FAM193B by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1205 - Jurkat Cell Lysate
 2) Cat. No. 17-005 - Jurkat Cell Slide
PREDICTED MOLECULAR WEIGHT:99 kDa
SPECIFICITY:At least two isoforms of FAM193B are known to exist; this antibody will detect both isoforms.
IMMUNOGEN:FAM193B antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human FAM193B.

The immunogen is located within amino acids 120 - 170 of FAM193B.
HOST SPECIES:Rabbit

Properties

PURIFICATION:FAM193B Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:FAM193B Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:FAM193B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:FAM193B Antibody: IRIZIO, KIAA1931, Protein FAM193B
ACCESSION NO.:Q96PV7
PROTEIN GI NO.:205831282
OFFICIAL SYMBOL:FAM193B
GENE ID:54540

Background

BACKGROUND:FAM193B Antibody: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.
REFERENCES: 1) Picchione F, Pritchard C, Lagutina I, et al. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS). Carcinogenesis 2011; 32:452-62.
2) Linardic CM. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett. 2008; 270:10-8.

For Research Use Only